The Effect of Combination of Calcium Supplement and Physical Exercise on Increasing Muscle Strength in Chronic Ischemic Stroke

Main Article Content

Nurjannah
Audry Devisanty Wuysang
Andi Aryandy
Ashari Bahar
Cahyono Kaelan
Aryadi Arsyad
Corresponding Author:
Nurjannah | nannatadjuddin@gmail.com



Abstract

Background: Stroke causes muscle weakness which results in limitations in daily activities such as self-care, eating, walking, etc. Objective: This study aims to evaluate the effect of calcium supplement and physical exercise on increasing muscle strength in chronic ischemic stroke patients. Method: This research used a quasi-experimental pretest-posttest with control group design. This research was conducted at Dadi Makassar Hospital and Haji Hospital from March to May 2023. The sample obtained was 37 subjects based purposive sampling with an unpaired numerical comparative formula for two sample groups. Consisting of 18 people in the treatment group who were given calcium supplements at a dose of 500 mg per day and physical exercise (Both training, Proprioceptive Neuromuscular Facilitation (PNF) and strengthening) and 19 people in the control group who were only given physical exercise. The research was carried out for 6 weeks using a Manual Muscle Testing (MMT) measuring instrument for muscle strength. This research used the Wilcoxon and Mann Whitney test. (α<0.05) Results: There is a significant of increasing lower extremity muscle strength between pretest and posttest in treatment group and control group (p=0.001; p=0.014, p<0.05), There is an increasing of the upper extremity muscle strength between pretest and posttest in treatment group and control group (p=0.001; p=0.025). There is no significant difference of increasing muscle strength in the upper and lower limb between two groups (p=0.051). Conclusion: Calcium supplements and physical exercise were no more significant in increasing muscle strength than physical exercise only in chronic ischemic stroke patients.

Article Details

How to Cite
[1]
Nurjannah, A. D. Wuysang, A. Aryandy, A. Bahar, C. Kaelan, and A. Arsyad, “The Effect of Combination of Calcium Supplement and Physical Exercise on Increasing Muscle Strength in Chronic Ischemic Stroke”, Babali Nurs. Res., vol. 4, no. 4, pp. 605-617, Oct. 2023.
Section
Original Research
Author Biographies

Nurjannah, Hasanuddin University, Makassar, South Sulawesi, Indonesia

Department of Biomedical Sciences, Faculty of Postgraduate

Audry Devisanty Wuysang, Hasanuddin University, Makassar, South Sulawesi, Indonesia

Department of Neurology, Faculty of Medicine

Andi Aryandy, Hasanuddin University, Makassar, South Sulawesi, Indonesia

Department of Physiology, Faculty of Medicine

Ashari Bahar, Hasanuddin University, Makassar, South Sulawesi, Indonesia

Department of Neurology, Faculty of Medicine

Cahyono Kaelan, Hasanuddin University, Makassar, South Sulawesi, Indonesia

Department of Neurology, Faculty of Medicine

Aryadi Arsyad, Hasanuddin University, Makassar, South Sulawesi, Indonesia

Department of Physiology, Faculty of Medicine

References

[1] Feigin F.L Michael B, Bo Norrving, Sheila M, Ralph L S, Werner H, Marc F, Jeyaraj
P, and Patrice L ., “World Stroke Organization (WSO): Global Stroke Fact Sheet 2022,” Int. J. Stroke, vol. 17, no. 1, pp. 18–29, 2022, doi: 10.1177/17474930211065917.
[2] Azzollini V, S. Dalise, and C. Chisari, “How Does Stroke Affect Skeletal Muscle? State of the Art and Rehabilitation Perspective,” Front. Neurol., vol. 12, no. December, 2021, doi: 10.3389/fneur.2021.797559.
[3] Wang H, Y. Huang, and Y. Zhao, “Efficacy of Exercise on Muscle Function and Physical Performance in Older Adults with Sarcopenia: An Updated Systematic Review and Meta-Analysis,” Int. J. Environ. Res. Public Health, vol. 19, no. 13, 2022, doi: 10.3390/ijerph19138212.
[4] Thongprayoon C, W. Cheungpasitporn, A. Chewcharat, M. A. Mao, and K. B. Kashani, “Serum ionised calcium and the risk of acute respiratory failure in hospitalised patients: a single-centre cohort study in the USA,” BMJ Open, vol. 10, no. 3, p. e034325, 2020, doi: 10.1136/bmjopen-2019-034325.
[5] Du Y, C. Oh, and J. No, “Is Calcium the Main Nutrient in the Diet Plan for Sarcopenia among the Elderly? A Systematic Review and Meta-Analysis,” pp. 1–16, 2022, [Online]. Available: https://doi.org/10.21203/rs.3.rs-1359964/v1
[6] Abumrad N.A, A. G. Cabodevilla, D. Samovski, T. Pietka, D. Basu, and I. J. Goldberg, “Endothelial Cell Receptors in Tissue Lipid Uptake and Metabolism,” Circ. Res., vol. 128, no. 3, pp. 433–450, 2021, doi: 10.1161/CIRCRESAHA.120.318003.
[7] Yusni Y and A. Amiruddin, “Efek suplementasi kalsium terhadap kebugaran dan profil kesehatan pada atlet Tarung Derajat,” J. Keolahragaan, vol. 8, no. 1, pp. 42–51, 2020, doi: 10.21831/jk.v8i1.30244.
[8] Agrawal A, G. Suryakumar, and R. Rathor, “Role of defective Ca2+ signaling in skeletal muscle weakness: Pharmacological implications,” J. Cell Commun. Signal., vol. 12, no. 4, pp. 645–659, 2018, doi: 10.1007/s12079-018-0477-z.
[9] Hoffman J.R , T. Ben-Zeev, A. Zamir, C. Levi, and I. Ostfeld, “Examination of Amorphous Calcium Carbonate on the Inflammatory and Muscle Damage Response in Experienced Resistance Trained Individuals,” Nutrients, vol. 14, no. 9, 2022, doi: 10.3390/nu14091894.
[10] Lu L, L. Mao, Y. Feng, B. E. Ainsworth, Y. Liu, and N. Chen, “Effects of different exercise training modes on muscle strength and physical performance in older people with sarcopenia: a systematic review and meta-analysis,” BMC Geriatr., vol. 21, no. 1, pp. 1–30, 2021, doi: 10.1186/s12877-021-02642-8.
[11] Sopiyudin Dahlan, Besaran Sampel Penelitian, 4th ed. Jakarta: Epidemiologi Indonesia, 2016. [Online]. Available: Epidemiologi Indonesia@gmail.com
[12] Cuthbert S.C, G. J. Goodheart, “On the reliability and validity of manual muscle testing: A literature review,” Chiropr. Osteopat., vol. 15, no. May, 2007, doi: 10.1186/1746-1340-15-4.
[13] Bittmann F.N, S. Dech, M. Aehle, and L. V. Schaefer, “Manual muscle testing—force profiles and their reproducibility,” Diagnostics, vol. 10, no. 12, 2020, doi: 10.3390/diagnostics10120996.
[14] Nadimi H, Abolghassem D, Mohammad H.J, Ahmadreza D, Ehsan G, Hoda D, Hamed M, Seyedeh N.M, Mahmoud D, “Effect of Vitamin D supplementation on CREB-TrkB-BDNF pathway in the hippocampus of diabetic rats,” Iran. J. Basic Med. Sci., vol. 23, no. 1, pp. 117–123, 2020, doi: 10.22038/IJBMS.2019.38170.9068.
[15] Park S.S and Y. K. Seo, “Excess accumulation of lipid impairs insulin sensitivity in skeletal muscle,” Int. J. Mol. Sci., vol. 21, no. 6, 2020, doi: 10.3390/ijms21061949.
[16] Hargreaves M. and L. L. Spriet, “Exercise metabolism: Fuels for the fire,” Cold Spring Harb. Perspect. Med., vol. 8, no. 8, pp. 1–15, 2018, doi: 10.1101/cshperspect.a029744.
[17] Bai M, Rui W, Linhao Z, Guixin L, Dongya Y, Li W, Tianbo J, “Age-related differences in limb fat-free mass and fat mass in healthy Chinese Adults,” Sci. Rep., vol. 8, no. 1, pp. 1–8, 2018, doi: 10.1038/s41598-018-25447-z.
[18] Gejl K.D, E. P. Andersson, J. Nielsen, H. C. Holmberg, and N. Ørtenblad, “Effects of Acute Exercise and Training on the Sarcoplasmic Reticulum Ca2+ Release and Uptake Rates in Highly Trained Endurance Athletes,” Front. Physiol., vol. 11, no. July, pp. 1–11, 2020, doi: 10.3389/fphys.2020.00810.
[19] Emad E.M, A. S. E. Elmotaym, M. A. Ghonemy, and A. E. Badawy, “The effect of hypocalcemia on motor symptoms of Parkinson’s disease,” Egypt. J. Neurol. Psychiatry Neurosurg., vol. 58, no. 1, pp. 1–7, 2022, doi: 10.1186/s41983-022-00499-1.
[20] Imierska M, A. Kurianiuk, and A. Błachnio-Zabielska, “The influence of physical activity on the bioactive lipids metabolism in obesity-induced muscle insulin resistance,” Biomolecules, vol. 10, no. 12, pp. 1–20, 2020, doi: 10.3390/biom10121665.
[21] Kobayashi T, Nagomi K, Takashi M,, “Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations,” Nat. Commun., vol. 13, no. 1, pp. 1–15, 2022, doi: 10.1038/s41467-022-30429-x.
[22] Dirksen R.T, D. A. Eisner, R. Eduardo, and K. R. Sipido, “Excitation – Contraction Coupling Excitation – contraction coupling in cardiac , skeletal , and smooth muscle,” vol. 154, no. 9, pp. 9–11, 2022. doi: 08.357/gdjs.2022.231.
[23] Marchioretti C, Giulia Z, Gaia G, Leonardo N, Andreotti R, Paolo M, Lorenzo M, Marta C, Samir N, Emanuela Z, Mathilde C, Marco P,Anna R, Rosario R, Andrea M, Aram M, Gianni S , Elena P, Elisa B, Assunta P, Carlo B, Pietro R, Chiara R, Andrew L, Gopal B. Marco Snadri, Bert B, Manuela B, Marco P, Maria P., “Defective excitation-contraction coupling and mitochondrial respiration precede mitochondrial Ca2+ accumulation in spinobulbar muscular atrophy skeletal muscle,” Front. Physiol., vol. 11, no. July, pp. 1–11, 2023, doi: 10.3389/fphys.2020.00810.
[24] Chin C.W, Sung Chang, I-ting Liu, Fu-wen Liang, Chia-chun Li, Zih-jie Sun, Yin-fan Chang, Ting-hsing Chao, “Effects of age and gender on body composition indices as predictors of mortality in middle-aged and old people,” Sci. Rep., vol. 12, no. 1, pp. 1–17, 2022, doi: https://doi.org/10.1038/s41598-022-12048-0.
[25] Mohajan D and H. K. Mohajan, “Long-Term Regular Exercise Increases V̇O2max for Cardiorespiratory Fitness,” Innov. Sci. Technol., vol. 2, no. 2, pp. 38–43, 2023, doi: 10.56397/ist.2023.03.07.